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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:17712
Term: 9H-xanthine
Definition: An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Chemical ID: MESH:D019820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1amultiple interactionsISOHif1a (Rattus norvegicus)6480464CTD[Xanthine co-treated with XDH protein] inhibits the reaction [carbobenzoxy-leucyl-leucyl-leucine results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]PMID:12595275
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