GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Aif1 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of AIF1 mRNA | PMID:22228805 | Aif1 | multiple interactions | EXP | | 6480464 | CTD | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AIF1 mRNA; AHR protein affects the reaction [Benzo(a)pyrene affects the expression of AIF1 mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to AIF1 promoter] | PMID:19654925 PMID:22228805 PMID:27858113 | Aif1 | affects methylation | ISO | AIF1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of AIF1 promoter | PMID:27901495 | Aif1 | increases expression | ISO | AIF1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of AIF1 protein | PMID:34332006 | |
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