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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62217
Species: Mus musculus
RGD Object: Gene
Symbol: Aif1
Name: allograft inflammatory factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aif1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of AIF1 mRNAPMID:22228805
Aif1multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AIF1 mRNA; AHR protein affects the reaction [Benzo(a)pyrene affects the expression of AIF1 mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to AIF1 promoter]PMID:19654925 PMID:22228805 PMID:27858113
Aif1affects methylationISOAIF1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of AIF1 promoterPMID:27901495
Aif1increases expressionISOAIF1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of AIF1 proteinPMID:34332006
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