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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62211
Species: Mus musculus
RGD Object: Gene
Symbol: Slc30a1
Name: solute carrier family 30 (zinc transporter), member 1
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc30a1affects localizationEXP 6480464CTDZinc Sulfate affects the localization of SLC30A1 proteinPMID:14608047
Slc30a1decreases expressionEXP 6480464CTDZinc Sulfate deficiency results in decreased expression of SLC30A1 mRNAPMID:10952993
Slc30a1increases expressionEXP 6480464CTDZinc Sulfate results in increased expression of SLC30A1 mRNAPMID:10952993 PMID:14608047 PMID:15142038
Slc30a1multiple interactionsEXP 6480464CTD1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA]; Dicumarol inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA]; Staurosporine inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA]PMID:15142038
Slc30a1decreases expressionISOSlc30a1 (Rattus norvegicus)6480464CTDZinc Sulfate deficiency results in decreased expression of SLC30A1 mRNAPMID:11208937
Slc30a1increases expressionISOSlc30a1 (Rattus norvegicus)6480464CTDZinc Sulfate results in increased expression of SLC30A1 mRNA; Zinc Sulfate results in increased expression of SLC30A1 proteinPMID:11208937 PMID:19679144 PMID:9560190
Slc30a1increases expressionISOSLC30A1 (Homo sapiens)6480464CTDZinc Sulfate results in increased expression of SLC30A1 mRNA; Zinc Sulfate results in increased expression of SLC30A1 proteinPMID:12756304 PMID:15226459 PMID:16330358 PMID:17018880 PMID:19083439 PMID:21883094 PMID:25162517 PMID:25895165
Slc30a1multiple interactionsISOSLC30A1 (Homo sapiens)6480464CTDMTF1 mutant form inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA]; PTEN mutant form inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA]; Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of SLC30A1 mRNA]PMID:17018880 PMID:21883094
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