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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62202
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h3multiple interactionsEXP 6480464CTD[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of NR1H3 mRNAPMID:23428407 PMID:24848799
Nr1h3decreases expressionISONr1h3 (Rattus norvegicus)6480464CTDDexamethasone results in decreased expression of NR1H3 mRNAPMID:20888898
Nr1h3increases expressionISONr1h3 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of NR1H3 mRNAPMID:20032058
Nr1h3increases expressionISONR1H3 (Homo sapiens)6480464CTDDexamethasone results in increased expression of NR1H3 mRNAPMID:19022236 PMID:25047013
Nr1h3multiple interactionsISONr1h3 (Rattus norvegicus)6480464CTDTestosterone inhibits the reaction [Dexamethasone results in increased expression of NR1H3 mRNA]PMID:20032058
Nr1h3multiple interactionsISONR1H3 (Homo sapiens)6480464CTD[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA; bexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]; rosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]PMID:25932594
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