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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621871
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt-co1
Name: mitochondrially encoded cytochrome c oxidase I
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt-co1decreases activityEXP 6480464CTDDoxorubicin results in decreased activity of COX1 proteinPMID:14568902 PMID:19747854
Mt-co1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of COX1 mRNA; Doxorubicin results in decreased expression of COX1 proteinPMID:14736955 PMID:17131338 PMID:19217856 PMID:28865727
Mt-co1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of COX1 mRNAPMID:30557669
Mt-co1decreases expressionISOMT-CO1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of COX1 mRNA; Doxorubicin results in decreased expression of COX1 proteinPMID:26781513 PMID:29803840
Mt-co1increases expressionISOMT-CO1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of COX1 proteinPMID:26781513
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