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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf4
Name: activating transcription factor 4
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf4increases expressionEXP 6480464CTDThapsigargin results in increased expression of ATF4 proteinPMID:28844859
Atf4multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]PMID:28844859
Atf4decreases response to substanceISOATF4 (Homo sapiens)6480464CTDATF4 results in decreased susceptibility to ThapsigarginPMID:20022965
Atf4increases activityISOATF4 (Homo sapiens)6480464CTDThapsigargin results in increased activity of ATF4 proteinPMID:23383089
Atf4increases expressionISOATF4 (Homo sapiens)6480464CTDThapsigargin results in increased expression of ATF4 mRNA; Thapsigargin results in increased expression of ATF4 proteinPMID:16298333 PMID:17283163 PMID:20022965 PMID:22378314 PMID:23741617 PMID:24865413 PMID:27358234 PMID:27587023 PMID:32357311
Atf4increases expressionISOAtf4 (Mus musculus)6480464CTDThapsigargin results in increased expression of ATF4 mRNA; Thapsigargin results in increased expression of ATF4 proteinPMID:20589738 PMID:24648495 PMID:27226639 PMID:28223344 PMID:29109149 PMID:32578922
Atf4multiple interactionsISOATF4 (Homo sapiens)6480464CTD2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA]; ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; NUPR1 mutant form promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Thapsigargin promotes the reaction [ATF4 protein binds to PMAIP1 promoter]PMID:16298333 PMID:20022965 PMID:23741617
Atf4multiple interactionsISOAtf4 (Mus musculus)6480464CTD2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; ATF4 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; GSK2656157 inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]PMID:24648495 PMID:29109149 PMID:32578922
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