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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf4
Name: activating transcription factor 4
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf4decreases response to substanceISOATF4 (Homo sapiens)6480464CTDATF4 results in decreased susceptibility to BortezomibPMID:20022965
Atf4increases expressionISOATF4 (Homo sapiens)6480464CTDBortezomib results in increased expression of ATF4 mRNA; Bortezomib results in increased expression of ATF4 proteinPMID:15509775 PMID:16928686 PMID:20022965
Atf4increases expressionISOAtf4 (Mus musculus)6480464CTDBortezomib results in increased expression of ATF4 proteinPMID:15509775
Atf4multiple interactionsISOATF4 (Homo sapiens)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]; ATF4 mutant form inhibits the reaction [Bortezomib results in increased expression of PMAIP1 mRNA]; ATF4 mutant form inhibits the reaction [Bortezomib results in increased expression of PMAIP1 protein]; Bortezomib promotes the reaction [ATF4 protein binds to PMAIP1 promoter]; Dactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]; NUPR1 mutant form promotes the reaction [Bortezomib results in increased expression of ATF4 mRNA]PMID:15509775 PMID:20022965
Atf4multiple interactionsISOAtf4 (Mus musculus)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]PMID:15509775
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