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GENE - TERM ANNOTATION REPORT

RGD ID: 621852
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnnt1
Name: troponin T1, slow skeletal type
Acc ID: DOID:384
Term: Wolff-Parkinson-White syndrome
Definition: A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
Definition Source(s): MESH:D014927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnnt1 ISOTNNT1 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White SyndromePMID:18414213 PMID:24033266 PMID:25741868 PMID:28492532
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