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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621805
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd17b3decreases activityEXP 6480464CTDDoxorubicin results in decreased activity of HSD17B3 proteinPMID:24593989
Hsd17b3decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of HSD17B3 mRNAPMID:24593989
Hsd17b3multiple interactionsEXP 6480464CTDPropolis inhibits the reaction [Doxorubicin results in decreased activity of HSD17B3 protein]; Propolis inhibits the reaction [Doxorubicin results in decreased expression of HSD17B3 mRNA]PMID:24593989
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