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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621759
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vwf
Name: von Willebrand factor
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vwfincreases expressionISOVWF (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of VWF mRNAPMID:20580663 PMID:29571895
Vwfincreases expressionISOVwf (Mus musculus)6480464CTDCadmium Chloride results in increased expression of VWF mRNA; Cadmium Chloride results in increased expression of VWF proteinPMID:29571895
Vwfmultiple interactionsISOVWF (Homo sapiens)6480464CTDCadmium Chloride promotes the reaction [ERG protein binds to VWF promoter]; ERG protein affects the reaction [Cadmium Chloride results in increased expression of VWF mRNA]; ERG protein affects the reaction [Cadmium Chloride results in increased expression of VWF protein]PMID:29571895
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