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RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: GO:0070059
Term: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Definition: A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Definition Source(s): GOC:mah, GOC:mtg_apoptosis, PMID:18701708
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IEAUniProtKB:O08736, ensembl:ENSMUSP000000270091600115EnsemblGO_REF:0000107

 ISORGD:7314421624291RGDMGI:MGI:1097161, MGI:MGI:99702 (MGI:MGI:1351404, PMID:10638761), (MGI:MGI:2667259, PMID:12847083), (MGI:MGI:5634893, PMID:12097332)

MGI:MGI:1351404, MGI:MGI:2667259, MGI:MGI:5634893, PMID:10638761, PMID:12097332, PMID:12847083
 NAS 10047306ParkinsonsUK-UCLPMID:10638761

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.