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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDThapsigargin results in increased activity of CASP12 protein

PMID:18477628
increases cleavageEXP 6480464CTDThapsigargin results in increased cleavage of CASP12 protein alternative form

PMID:16338971
increases activityISORGD:13480776480464CTDThapsigargin results in increased activity of CASP12 protein

PMID:24224909
increases activityISORGD:7314426480464CTDThapsigargin results in increased activity of CASP12 protein

PMID:20493918
increases cleavageISORGD:13480776480464CTDThapsigargin results in increased cleavage of CASP12 protein

PMID:12198651
increases expressionISORGD:13480776480464CTDThapsigargin results in increased expression of CASP12 protein modified form

PMID:26264395
multiple interactionsISORGD:13480776480464CTDdemethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form], resveratrol inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein], tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased cleavage of CASP12 protein]

PMID:12198651, PMID:24224909, PMID:26264395
multiple interactionsISORGD:7314426480464CTDApigenin inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein], Thapsigargin promotes the reaction [arsenic trioxide results in increased expression of CASP12 protein modified form]

PMID:20493918, PMID:27638049
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.