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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageEXP 6480464CTDmanganese chloride results in increased cleavage of CASP12 protein

PMID:25732873
increases expressionEXP 6480464CTDmanganese chloride results in increased expression of CASP12 mRNA, manganese chloride results in increased expression of CASP12 protein

PMID:23934647, PMID:23948121, PMID:28801915
multiple interactionsEXP 6480464CTDSNCA protein promotes the reaction [manganese chloride results in increased expression of CASP12 protein]

PMID:23934647
increases cleavageISORGD:7314426480464CTDmanganese chloride results in increased cleavage of CASP12 protein

PMID:26064043
multiple interactionsISORGD:13480776480464CTDDeferoxamine promotes the reaction [manganese chloride results in increased cleavage of and results in increased activity of CASP12 protein], manganese chloride results in increased cleavage of and results in increased activity of CASP12 protein

PMID:23764342
multiple interactionsISORGD:7314426480464CTDPlant Extracts inhibits the reaction [manganese chloride results in increased cleavage of CASP12 protein]

PMID:26064043
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.