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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of CASP12 protein

PMID:19576244
multiple interactionsEXP 6480464CTD2, 4, 5, 2', 4', 5'-hexachlorobiphenyl promotes the reaction [2, 2', 4, 4'-tetrabromodiphenyl ether results in increased expression of CASP12 mRNA], [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with 2, 2', 4, 4'-tetrabromodiphenyl ether] results in increased expression of CASP12 protein

PMID:19576244
increases expressionISORGD:13480776480464CTD2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of CASP12 protein

PMID:19022289
multiple interactionsISORGD:13480776480464CTD2, 4, 5, 2', 4', 5'-hexachlorobiphenyl promotes the reaction [2, 2', 4, 4'-tetrabromodiphenyl ether results in increased expression of CASP12 mRNA], 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl promotes the reaction [2, 2', 4, 4'-tetrabromodiphenyl ether results in increased expression of CASP12 protein]

PMID:19022289
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.