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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [arsenic trioxide results in increased cleavage of CASP12 protein], Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP12 protein], Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA], Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]

PMID:18077580, PMID:21145380, PMID:28296042
multiple interactionsISORGD:7314426480464CTDAcetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein], Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]]

PMID:21616140, PMID:25451595
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.