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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDresveratrol affects the expression of CASP12 mRNA

PMID:17959022
increases expressionISORGD:13480776480464CTDresveratrol results in increased expression of CASP12 protein

PMID:24264887
multiple interactionsISORGD:13480776480464CTDCASP12 mutant form inhibits the reaction [Resveratrol results in increased cleavage of PARP1 protein], Resveratrol inhibits the reaction [Ethanol results in increased activity of CASP12 protein], Resveratrol inhibits the reaction [Ethanol results in increased expression of CASP12 protein modified form], Resveratrol inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein], Resveratrol inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein]

PMID:24224909, PMID:24264887
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.