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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:27869
Term: chloroacetic acid
Definition: A chlorocarboxylic acid that is acetic acid carrying a 2-chloro substituent.
Chemical ID: MESH:C006972
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7314426480464CTDAcetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein], chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein, HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein], HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]

PMID:25451595
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.