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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:7314426480464CTDCadmium results in increased activity of CASP12 protein

PMID:20600546
multiple interactionsISORGD:13480776480464CTD1, 2-bis(2-aminophenoxy)ethane N, N, N', N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium results in increased cleavage of and results in increased activity of CASP12 protein], Cadmium results in increased cleavage of and results in increased activity of CASP12 protein

PMID:19442655
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.