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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:17963
Term: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Definition: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Chemical ID: MESH:D015632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageISORGD:7314426480464CTD1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased cleavage of CASP12 protein

PMID:24140863
increases expressionISORGD:7314426480464CTD1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of CASP12 mRNA

PMID:20230807
multiple interactionsISORGD:13480776480464CTDTXN protein inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased cleavage of CASP12 protein]

PMID:24140863
multiple interactionsISORGD:7314426480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine] results in increased expression of CASP12 mRNA, Nicotine inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of CASP12 mRNA]

PMID:20230807
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.