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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:13480776480464CTDEthanol results in increased activity of CASP12 protein

PMID:24224909
increases cleavageISORGD:7314426480464CTDEthanol results in increased cleavage of CASP12 protein

PMID:28119953
increases expressionISORGD:13480776480464CTDEthanol results in increased expression of CASP12 protein modified form

PMID:24224909
increases expressionISORGD:7314426480464CTDEthanol results in increased expression of CASP12 protein

PMID:27983966
multiple interactionsISORGD:13480776480464CTDResveratrol inhibits the reaction [Ethanol results in increased activity of CASP12 protein], Resveratrol inhibits the reaction [Ethanol results in increased expression of CASP12 protein modified form]

PMID:24224909
multiple interactionsISORGD:7314426480464CTDCimetidine inhibits the reaction [Ethanol results in increased expression of CASP12 protein], Drugs, Chinese Herbal inhibits the reaction [Ethanol results in increased expression of CASP12 protein], Hydralazine inhibits the reaction [Ethanol results in increased cleavage of CASP12 protein]

PMID:27983966, PMID:28119953
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.