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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp4
Name: caspase 4
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp4increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of CASP4 mRNAPMID:19730151
Casp4increases activityISOCASP4 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of CASP4 proteinPMID:20138156
Casp4increases cleavageISOCASP4 (Homo sapiens)6480464CTDArsenic Trioxide results in increased cleavage of CASP4 proteinPMID:25258189
Casp4increases expressionISOCASP4 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CASP4 mRNAPMID:11940349 PMID:24345465
Casp4multiple interactionsISOCASP4 (Homo sapiens)6480464CTD[sanguinarine co-treated with Arsenic Trioxide] results in increased expression of CASP4 mRNA; [sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of CASP4 protein; Acetylcysteine inhibits the reaction [[sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of CASP4 protein]; Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CASP4 protein]; isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Arsenic Trioxide results in increased activity of CASP4 protein]PMID:20138156 PMID:22922937 PMID:24345465 PMID:26598702
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