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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDCyclophosphamide results in decreased activity of GSR proteinPMID:25446862 PMID:25753322 PMID:33992719
Gsrmultiple interactionsEXP 6480464CTDnaringin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]PMID:25446862 PMID:25753322 PMID:33992719
Gsrdecreases activityISOGsr (Mus musculus)6480464CTDCyclophosphamide results in decreased activity of GSR proteinPMID:21772021 PMID:23542512
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTD[[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide; [Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein; Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]PMID:12114195 PMID:21772021
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