Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsraffects activityEXP 6480464CTDCadmium Chloride affects the activity of GSR proteinPMID:16865233
Gsraffects expressionEXP 6480464CTDCadmium Chloride affects the expression of GSR mRNA; Cadmium Chloride affects the expression of GSR proteinPMID:20107868 PMID:22957049
Gsraffects methylationEXP 6480464CTDCadmium Chloride affects the methylation of GSR promoterPMID:22957049
Gsrdecreases activityEXP 6480464CTDCadmium Chloride results in decreased activity of GSR proteinPMID:16962696 PMID:19958828 PMID:21134734 PMID:21911053 PMID:23961183 PMID:24200859 PMID:25265456
Gsrdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of GSR mRNA; Cadmium Chloride results in decreased expression of GSR proteinPMID:19063931 PMID:28110594 PMID:32392679
Gsrincreases activityEXP 6480464CTDCadmium Chloride results in increased activity of GSR proteinPMID:21911053 PMID:23726800
Gsrincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of GSR mRNAPMID:33453195
Gsrmultiple interactionsEXP 6480464CTD[Cadmium Chloride co-treated with Melatonin] results in decreased expression of GSR mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of GSR protein; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; Fra a 1 allergen, Fragaria ananassa inhibits the reaction [Cadmium Chloride results in decreased expression of GSR protein]; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of GSR protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of GSR mRNA]; Quercetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; zinc chloride inhibits the reaction [Cadmium Chloride results in increased activity of GSR protein]PMID:16962696 PMID:19063931 PMID:19958828 PMID:21134734 PMID:21442002 PMID:21911053 PMID:23726800 PMID:23961183 PMID:24200859 PMID:25265456 PMID:28110594 PMID:32392679 PMID:35384154
Gsrdecreases activityISOGSR (Homo sapiens)6480464CTDCadmium Chloride results in decreased activity of GSR proteinPMID:37336463
Gsrdecreases activityISOGsr (Mus musculus)6480464CTDCadmium Chloride results in decreased activity of GSR proteinPMID:17262218 PMID:18414974 PMID:18548748 PMID:18561905 PMID:21420465
Gsrdecreases expressionISOGSR (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of GSR mRNAPMID:12760830
Gsrincreases expressionISOGSR (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of GSR mRNAPMID:25596134 PMID:25882684 PMID:26525392
Gsrincreases expressionISOGsr (Mus musculus)6480464CTDCadmium Chloride results in increased expression of GSR mRNAPMID:20883709 PMID:25528414
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTDvanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]PMID:37336463
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTDarjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; Ascorbic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; Plant Preparations inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; Taurine inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]PMID:17262218 PMID:18414974 PMID:18548748 PMID:18561905 PMID:21420465
Go Back to source page   Continue to Ontology report