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GENE - TERM ANNOTATION REPORT

RGD ID: 621742
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cul5
Name: cullin 5
Acc ID: GO:0019005
Term: SCF ubiquitin ligase complex
Definition: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Definition Source(s): PMID:15571813, PMID:15688063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cul5part_ofIBAFB:FBgn0015509 or MGI:1349658 or PANTHER:PTN000231993 or PomBase:SPAC17G6.12 or SGD:S000002290 or UniProtKB:Q136161600115GO_CentralGO_REF:0000033

GO_REF:0000033
Cul5part_ofIEAPANTHER:PTHR11932:SF761600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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