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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2increases expressionISOACTA2 (Homo sapiens)6480464CTDzoledronic acid results in increased expression of ACTA2 proteinPMID:28871336
Acta2increases expressionISOActa2 (Mus musculus)6480464CTDzoledronic acid results in increased expression of ACTA2 proteinPMID:28871336
Acta2multiple interactionsISOACTA2 (Homo sapiens)6480464CTD4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein]PMID:28871336
Acta2multiple interactionsISOActa2 (Mus musculus)6480464CTDFenofibrate inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein]PMID:28871336
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