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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621675
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Timp1
Name: TIMP metallopeptidase inhibitor 1
Acc ID: CHEBI:31642
Term: gadodiamide hydrate
Definition: The hydrate of gadodiamide.
Chemical ID: MESH:C064925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1increases expressionEXP 6480464CTDgadodiamide results in increased expression of TIMP1 proteinPMID:20938346
Timp1increases expressionISOTIMP1 (Homo sapiens)6480464CTDgadodiamide results in increased expression of TIMP1 mRNA; gadodiamide results in increased expression of TIMP1 proteinPMID:19561517
Timp1multiple interactionsISOTIMP1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [gadodiamide results in increased expression of TIMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of TIMP1 protein]PMID:19561517
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