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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621660
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj12
Name: potassium inwardly-rectifying channel, subfamily J, member 12
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj12decreases expressionEXP 6480464CTDGenistein results in decreased expression of KCNJ12 mRNAPMID:21782745
Kcnj12multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Genistein] results in increased methylation of KCNJ12 gene; [Genistein co-treated with Methoxychlor] results in decreased expression of KCNJ12 mRNAPMID:21782745 PMID:28505145
Kcnj12increases expressionISOKcnj12 (Mus musculus)6480464CTDGenistein results in increased expression of KCNJ12 mRNAPMID:32186404
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