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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621646
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vim
Name: vimentin
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vimdecreases expressionEXP 6480464CTDcobaltous chloride results in decreased expression of VIM proteinPMID:12819242
Vimincreases expressionISOVIM (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of VIM mRNA; cobaltous chloride results in increased expression of VIM proteinPMID:19376846 PMID:26174737 PMID:35248696
Vimmultiple interactionsISOVIM (Homo sapiens)6480464CTDcobaltous chloride inhibits the reaction [Cyclosporine results in increased expression of VIM protein]; dorsomorphin promotes the reaction [cobaltous chloride results in increased expression of VIM protein]; SLC31A1 mutant form inhibits the reaction [cobaltous chloride results in increased expression of VIM mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VIM mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VIM protein]PMID:22343435 PMID:26174737 PMID:35248696
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