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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1decreases expressionISOBAK1 (Homo sapiens)6480464CTDCurcumin results in decreased expression of BAK1 mRNAPMID:33582110
Bak1increases expressionISOBAK1 (Homo sapiens)6480464CTDCurcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 proteinPMID:17332930 PMID:18226269
Bak1increases expressionISOBak1 (Mus musculus)6480464CTDCurcumin results in increased expression of BAK1 proteinPMID:17277231
Bak1increases response to substanceISOBak1 (Mus musculus)6480464CTDBAK1 protein results in increased susceptibility to CurcuminPMID:17277231
Bak1multiple interactionsISOBAK1 (Homo sapiens)6480464CTDTNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]PMID:18226269
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