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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621625
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aurkb
Name: aurora kinase B
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aurkbaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of AURKB mRNAPMID:22298810 PMID:34747641
Aurkbaffects expressionISOAURKB (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of AURKB mRNAPMID:22574217
Aurkbaffects expressionISOAurkb (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of AURKB mRNAPMID:26377647
Aurkbincreases expressionISOAurkb (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of AURKB mRNAPMID:19465110
Aurkbmultiple interactionsISOAurkb (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AURKB mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AURKB promoter]PMID:17942748 PMID:19654925
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