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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:83605
Term: 3,5-diethoxycarbonyl-1,4-dihydrocollidine
Definition: A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.
Chemical ID: MESH:D003997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1affects response to substanceISOKeap1 (Mus musculus)6480464CTDKEAP1 gene affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidinePMID:30215777
Keap1decreases response to substanceISOKeap1 (Mus musculus)6480464CTDKEAP1 gene mutant form results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidinePMID:30825315
Keap1multiple interactionsISOKeap1 (Mus musculus)6480464CTDKEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]PMID:30825315
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