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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1affects bindingISOKeap1 (Mus musculus)6480464CTDArsenic binds to KEAP1 proteinPMID:19808700
Keap1affects response to substanceISOKeap1 (Mus musculus)6480464CTDKEAP1 protein affects the susceptibility to ArsenicPMID:19808700
Keap1increases expressionISOKEAP1 (Homo sapiens)6480464CTDArsenic results in increased expression of KEAP1 mRNA; Arsenic results in increased expression of KEAP1 proteinPMID:14567983
Keap1increases methylationISOKEAP1 (Homo sapiens)6480464CTDArsenic results in increased methylation of KEAP1 promoterPMID:29247444
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