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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased activity of CASP9 proteinPMID:22595511
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased cleavage of CASP9 proteinPMID:20055834 PMID:22578287
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[diallyl trisulfide results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP9 protein; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP9 protein]PMID:22578287 PMID:28571773
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