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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:6570
Term: lupeol
Definition: A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables.
Chemical ID: MESH:C010480
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDlupeol results in increased expression of CASP9 mRNA; lupeol results in increased expression of CASP9 proteinPMID:30506710
Casp9multiple interactionsISOCasp9 (Rattus norvegicus)6480464CTDlupeol inhibits the reaction [COL2A1 results in decreased expression of CASP9 protein]PMID:35446470
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