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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:2825
Term: aristolochic acid A
Definition: An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical ID: MESH:C000228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases expressionEXP 6480464CTDaristolochic acid I results in increased expression of CASP9 protein modified formPMID:26656393
Casp9increases expressionISOCasp9 (Rattus norvegicus)6480464CTDaristolochic acid I results in increased expression of CASP9 mRNA; aristolochic acid I results in increased expression of CASP9 proteinPMID:34167444 PMID:35850572 PMID:36037877
Casp9multiple interactionsISOCasp9 (Rattus norvegicus)6480464CTDaristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [aristolochic acid I results in increased expression of CASP9 protein]PMID:35850572 PMID:36037877
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