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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:16494
Term: lipoic acid
Definition: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDThioctic Acid results in increased activity of CASP9 proteinPMID:16990509
Casp9multiple interactionsISOCasp9 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]PMID:19951573 PMID:23830814 PMID:30605698
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDThioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]PMID:27544635
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