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RGD ID: 621531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gria1
Name: glutamate ionotropic receptor AMPA type subunit 1
Acc ID: GO:0032281
Term: AMPA glutamate receptor complex
Definition: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.
Definition Source(s): GOC:ef
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAMGI:MGI:95808, MGI:MGI:95809, MGI:MGI:95810, MGI:MGI:95811, PANTHER:PTN000438080, RGD:61862, RGD:61863, RGD:621531, RGD:7095813792537GO_CentralPMID:21873635

 IDA 8554136UniProtPMID:19265014

 IEAUniProtKB:P23818, ensembl:ENSMUSP000000444941600115EnsemblGO_REF:0000107

 ISORGD:7356851624291RGD MGI:MGI:3587474, MGI:MGI:5440375, PMID:15883194, PMID:22632720
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.