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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8decreases expressionISOMapk8 (Mus musculus)6480464CTDTretinoin results in decreased expression of MAPK8 mRNAPMID:22498432
Mapk8decreases phosphorylationISOMapk8 (Mus musculus)6480464CTDTretinoin results in decreased phosphorylation of MAPK8 proteinPMID:16084493
Mapk8increases activityISOMapk8 (Mus musculus)6480464CTDTretinoin results in increased activity of MAPK8 proteinPMID:21626648
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDTretinoin results in increased phosphorylation of MAPK8 proteinPMID:16619266
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDpyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of MAPK8 protein]; SPAG9 protein promotes the reaction [Tretinoin results in increased phosphorylation of MAPK8 protein]PMID:16619266 PMID:21626648
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