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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62147
Species: Mus musculus
RGD Object: Gene
Symbol: Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Acc ID: CHEBI:7983
Term: pentobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Chemical ID: MESH:D010424
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabra1multiple interactionsEXP 6480464CTDPentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]PMID:1712603
Gabra1affects expressionISOGabra1 (Rattus norvegicus)6480464CTDPentobarbital affects the expression of GABRA1 mRNAPMID:8787126
Gabra1decreases expressionISOGabra1 (Rattus norvegicus)6480464CTDPentobarbital results in decreased expression of GABRA1 mRNAPMID:8207435
Gabra1multiple interactionsISOGabra1 (Rattus norvegicus)6480464CTDPentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]PMID:12939268 PMID:1977069 PMID:2165521 PMID:8397295
Gabra1multiple interactionsISOGABRA1 (Homo sapiens)6480464CTD[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]PMID:10049148 PMID:9316872
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