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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621427
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Artn
Name: artemin
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Artnincreases expressionISOARTN (Homo sapiens)6480464CTDEstradiol results in increased expression of ARTN mRNA; Estradiol results in increased expression of ARTN proteinPMID:20305694 PMID:31614463
Artnmultiple interactionsISOARTN (Homo sapiens)6480464CTD[Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA; ARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; fulvestrant inhibits the reaction [Estradiol results in increased expression of ARTN mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ARTN mRNA]; YC137 inhibits the reaction [ARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]; YC137 inhibits the reaction [ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]PMID:20305694 PMID:24758408
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