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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Frk
Name: fyn-related Src family tyrosine kinase
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Frkdecreases expressionEXP 6480464CTDEstradiol results in decreased expression of FRK mRNAPMID:32145629
Frkincreases expressionISOFRK (Homo sapiens)6480464CTDEstradiol results in increased expression of FRK mRNAPMID:19619570 PMID:21185374 PMID:24758408 PMID:25321415 PMID:31614463
Frkmultiple interactionsISOFRK (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FRK mRNA; EGF protein promotes the reaction [Estradiol results in increased expression of FRK mRNA]PMID:19619570 PMID:24758408
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