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GENE - TERM ANNOTATION REPORT

RGD ID: 621420
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nbn
Name: nibrin
Acc ID: DOID:9007071
Term: Hereditary Neoplastic Syndromes
Definition: The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Definition Source(s): MESH:D009386
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:13486118554872ClinVarClinVar Annotator: match by null

 
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:10839544, PMID:12861053, PMID:21664921, PMID:25741868, PMID:26512707, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:12447395, PMID:15451479, PMID:15593232, PMID:25741868
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15048089, PMID:15758953, PMID:15964794, PMID:17429352, PMID:21035407, PMID:26467025, PMID:28152038, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16415040, PMID:25741868, PMID:26315354, PMID:28492532, PMID:9590180
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16415040, PMID:25741868, PMID:28492532, PMID:9590180
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16415040, PMID:28492532, PMID:9590180
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:17526493, PMID:17591703
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:17894553, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19105185
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:22491912, PMID:25741868, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:23525077, PMID:23555315, PMID:25741868, PMID:26976419, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:23555315, PMID:25741868, PMID:25980754, PMID:26086041, PMID:26976419, PMID:27443514, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:23555315, PMID:25741868, PMID:25980754, PMID:26467025, PMID:27443514, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24033266, PMID:24763289, PMID:25741868, PMID:26786923, PMID:26787654, PMID:26976419, PMID:27748766, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24349281
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24349281, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24549055, PMID:25741868, PMID:26315354, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24728327, PMID:25741868
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24728327, PMID:25741868, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24755471, PMID:24894818, PMID:25741868, PMID:26787654, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24894818, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25239263, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25356899, PMID:25741868
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25503501, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:25980754, PMID:26315354, PMID:27978560, PMID:28135145, PMID:28492532, PMID:28528518
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:25980754, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:25980754, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:26315354, PMID:26467025, PMID:27060854, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:26467025
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:26467025, PMID:26787654, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:26467025, PMID:28202063, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:26580448, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:26681312, PMID:28492532, PMID:29093764
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:26934577, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:27148588, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:27616075, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:28135145, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:28492532, PMID:28497333
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:28492532, PMID:30287823
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:26467025, PMID:26976419, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:26976419, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:27109316
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:28135145, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:10398434, PMID:10852373, PMID:11093281, PMID:11279524, PMID:11953735, PMID:12123493, PMID:12505263, PMID:12833396, PMID:14973119, PMID:15185344, PMID:16033915, PMID:16544999, PMID:17103455, PMID:18606567, PMID:18940477, PMID:19635536, PMID:19908051, PMID:20444919, PMID:22131123, PMID:22293976, PMID:22941933, PMID:23765759, PMID:24113799, PMID:25186627, PMID:25485873, PMID:25741868, PMID:25980754, PMID:26083025, PMID:26467025, PMID:26681312, PMID:26822949, PMID:26845104, PMID:27150568, PMID:27616075, PMID:28492532, PMID:9590180, PMID:9620777
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:10799436, PMID:12621246, PMID:18593981, PMID:22006311, PMID:23149842, PMID:24072268, PMID:24549055, PMID:25712764, PMID:25741868, PMID:26315354, PMID:26467025, PMID:28492532, PMID:9590180
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:11325820, PMID:12353271, PMID:16770759, PMID:16810201, PMID:17496786, PMID:18606567, PMID:20805886, PMID:22491912, PMID:24396275, PMID:24728327, PMID:24894818, PMID:25741868, PMID:26315354, PMID:26467025, PMID:26564480, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:11325820, PMID:12679336, PMID:14559852, PMID:16702373, PMID:16810201, PMID:19523210, PMID:23555315, PMID:24113799, PMID:24728327, PMID:25741868, PMID:26092435, PMID:26315354, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:11325820, PMID:14559852, PMID:15185344, PMID:16033915, PMID:16152606, PMID:16702373, PMID:16770759, PMID:16998789, PMID:17957789, PMID:18066092, PMID:18073374, PMID:18328813, PMID:19452044, PMID:19523210, PMID:19629396, PMID:19804755, PMID:19813148, PMID:20981092, PMID:22131123, PMID:22491912, PMID:22941933, PMID:23458873, PMID:24093751, PMID:24113799, PMID:24556621, PMID:24728327, PMID:24733792, PMID:24894818, PMID:24928521, PMID:25741868, PMID:26315354, PMID:26467025, PMID:26722329, PMID:26822949, PMID:26929905, PMID:27028851, PMID:27153395, PMID:27443514, PMID:27621404, PMID:28261280, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:11325820, PMID:14559852, PMID:15338273, PMID:16474176, PMID:16810201, PMID:17695489, PMID:17894553, PMID:17899368, PMID:18049891, PMID:18280732, PMID:19393249, PMID:19452044, PMID:19523210, PMID:19813148, PMID:19908051, PMID:21212067, PMID:21698754, PMID:22131123, PMID:22373003, PMID:23317186, PMID:23555315, PMID:24093751, PMID:24113799, PMID:24728327, PMID:24830725, PMID:25619955, PMID:25712764, PMID:25741868, PMID:25980754, PMID:26083025, PMID:26315354, PMID:26467025, PMID:26722329, PMID:27153395, PMID:27616075, PMID:27621404, PMID:28261280, PMID:28492532, PMID:29335925, PMID:30441849
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:11325820, PMID:14559852, PMID:25741868, PMID:25980754, PMID:26315354, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:12353271, PMID:19523210, PMID:22864661, PMID:24033266, PMID:25741868, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:12376507, PMID:12427538, PMID:23525077, PMID:24728327, PMID:24894818, PMID:25741868, PMID:26315354, PMID:26467025, PMID:26787654, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:12917199, PMID:24033266, PMID:24728327, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:14684699, PMID:23555315, PMID:24728327, PMID:25741868, PMID:26315354, PMID:26467025, PMID:26659599, PMID:26787654, PMID:26928227, PMID:26976419, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:15474156, PMID:25741868, PMID:26315354, PMID:26467025, PMID:26534844, PMID:26681312, PMID:28152038, PMID:28374160, PMID:28492532, PMID:9590180
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:17496786, PMID:24396275, PMID:25503501, PMID:25741868, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:17894553, PMID:21346221, PMID:25117502, PMID:25741868, PMID:26315354, PMID:26467025, PMID:26787654, PMID:26898890, PMID:27978560, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:18281469, PMID:24728327, PMID:25741868, PMID:26315354, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:19409520, PMID:25741868, PMID:27760322, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:19523210, PMID:22995991, PMID:24113799, PMID:24728327, PMID:25741868, PMID:25980754, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:20805886, PMID:23555315, PMID:25741868, PMID:25980754, PMID:26315354, PMID:28135145, PMID:28492532, PMID:30374176
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:20805886, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:22491912, PMID:25741868, PMID:27616075, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:22864661, PMID:23149842, PMID:25741868, PMID:26681312, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:23555315, PMID:25318351, PMID:25741868, PMID:25980754, PMID:26315354, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:24033266, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:24349281, PMID:24728327, PMID:25741868, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:24349281, PMID:25712764, PMID:25741868, PMID:25980754, PMID:26315354, PMID:26467025, PMID:26976419, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:24349281, PMID:25712764, PMID:25741868, PMID:26315354, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:24549055, PMID:25318351, PMID:25741868, PMID:25980754, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:24549055, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:24728327, PMID:25318351, PMID:25741868, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:24763289, PMID:25741868, PMID:28492532, PMID:28727877
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25503501, PMID:25712764, PMID:25741868, PMID:25980754, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25677497, PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:25980754
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:26168399, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:26315354, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:26315354, PMID:27498913, PMID:28135145, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:26315354, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:26467025, PMID:27978560, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:27443514, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:27978560, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:26315354
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:26467025
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:26467025, PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:28492532
 ISORGD:13486118554872ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:28492532, PMID:9590180
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.