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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:3647
Term: chlorpromazine
Definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Chemical ID: MESH:D002746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases activityISONr1i3 (Mus musculus)6480464CTDChlorpromazine results in increased activity of NR1I3 proteinPMID:12948398
Nr1i3increases expressionISONr1i3 (Mus musculus)6480464CTDChlorpromazine results in increased expression of NR1I3 mRNAPMID:22310298
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD[Chlorpromazine co-treated with Cholic Acids] affects the expression of NR1I3 mRNA; [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]PMID:10037683 PMID:17041008 PMID:27344345
Nr1i3multiple interactionsISONr1i3 (Mus musculus)6480464CTDNR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]PMID:12049174
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