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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:7772
Term: omeprazole
Definition: A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
Chemical ID: MESH:D009853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3affects expressionEXP 6480464CTDOmeprazole affects the expression of NR1I3 mRNAPMID:19483382
Nr1i3increases expressionEXP 6480464CTDOmeprazole results in increased expression of NR1I3 mRNAPMID:19118567
Nr1i3decreases metabolic processingISONr1i3 (Mus musculus)6480464CTDNR1I3 gene mutant form results in decreased metabolism of OmeprazolePMID:27434302
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