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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7310136480464CTDAcetaminophen affects the expression of CCN2 mRNA

PMID:25458485
affects expressionISORGD:7310146480464CTDAcetaminophen affects the expression of CCN2 mRNA

PMID:15606129, PMID:17562736
decreases expressionISORGD:7310136480464CTDAcetaminophen results in decreased expression of CCN2 mRNA

PMID:22230336
increases expressionISORGD:7310136480464CTDAcetaminophen results in increased expression of CCN2 mRNA

PMID:21420995
increases expressionISORGD:7310146480464CTDAcetaminophen results in increased expression of CCN2 mRNA

PMID:11264010, PMID:12392966, PMID:14550746
multiple interactionsISORGD:7310146480464CTDNOS2 protein inhibits the reaction [Acetaminophen results in increased expression of CCN2 mRNA], TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of CCN2 mRNA]

PMID:12392966, PMID:14550746
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.