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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:34159
Term: 15-deoxy-Delta(12,14)-prostaglandin J2
Definition: A prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions.
Chemical ID: MESH:C097240
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7310136480464CTD15-deoxy-delta(12, 14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein], 15-deoxy-delta(12, 14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA], SMAD2 protein modified form affects the reaction [15-deoxy-delta(12, 14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]]

PMID:19429239
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.