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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn2increases expressionEXP 6480464CTDEstradiol results in increased expression of CTGF mRNA; Estradiol results in increased expression of CTGF proteinPMID:32145629
Ccn2multiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CCN2 mRNAPMID:32741896
Ccn2affects expressionISOCCN2 (Homo sapiens)6480464CTDEstradiol affects the expression of CCN2 mRNAPMID:14699072 PMID:25321415
Ccn2increases expressionISOCCN2 (Homo sapiens)6480464CTDEstradiol results in increased expression of CCN2 mRNA; Estradiol results in increased expression of CCN2 proteinPMID:19153601 PMID:25616260 PMID:31646340 PMID:35588983
Ccn2increases expressionISOCcn2 (Mus musculus)6480464CTDEstradiol results in increased expression of CCN2 mRNAPMID:19484750
Ccn2multiple interactionsISOCCN2 (Homo sapiens)6480464CTD[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CCN2 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of CCN2 mRNA; ESR1 protein promotes the reaction [Estradiol results in increased expression of CCN2 protein]; Estradiol inhibits the reaction [Fulvestrant results in increased expression of CCN2 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCN2 mRNA]; GPER1 protein promotes the reaction [Estradiol results in increased expression of CCN2 protein]PMID:20823114 PMID:25616260 PMID:30165855 PMID:31646340
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