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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA], Quercetin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA], Quercetin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein], Quercetin inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]

PMID:15573758, PMID:22989100, PMID:24117263
decreases expressionISORGD:7310136480464CTDQuercetin results in decreased expression of CCN2 mRNA

PMID:21632981
multiple interactionsISORGD:7310146480464CTDQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCN2 mRNA]

PMID:22915297
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.