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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621391
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Acc ID: CHEBI:31897
Term: nateglinide
Definition: An N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-administered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus.
Chemical ID: MESH:C060142
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco2b1multiple interactionsISOSLCO2B1 (Homo sapiens)6480464CTDNateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]PMID:23121773
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