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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621359
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfaip6
Name: TNF alpha induced protein 6
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaip6increases expressionEXP 6480464CTDParaquat results in increased expression of TNFAIP6 mRNAPMID:32680482
Tnfaip6multiple interactionsISOTNFAIP6 (Homo sapiens)6480464CTDTNFAIP6 protein inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; TNFAIP6 protein inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; TNFAIP6 protein inhibits the reaction [Paraquat results in increased expression of TNF mRNA]PMID:24912639 PMID:26313688
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